The Moby Dick Card Game is another Kickstarter project. It was fully funded, and the first run has shipped. The artwork looks terrific, but the game is unavailable to the general public at present.
Even without a knowledge of the novel, playing the game will clue you into the relationships between key sailors and the various perils and processes of hunting whales in the 19th century.
As important as the visuals are, the game could not exist without Melville's voice. Every card features a choice quotation from the book, tying the action at hand to the grand tale itself.
Hat tip: Kiwi.