Updated 12/27/2019 to include video stream and #mobydickmarathon hashtag.
If you're planning your first MDM, you'll find some practical advice in this post from 2011 and in the "Essentials" section at the right of this page. Check out the Whaling Museum's MDM page, too.
For stay-at-homes, a live video stream will commence at 11:30 AM, Saturday.
If you are set to be a Reader, here's a list of uncommon words you might encounter (courtesy of the 2014 NYC MDM).
...and be sure to follow #MDM24 & #mobydickmarathon on Twitter.